TOWARDS A NEW PREDICTOR OF AIDS PROGRESSION THROUGH THE QUANTITATION OF HIV-1 DNA COPIES BY PCR IN HIV-INFECTED INDIVIDUALS

被引：21

作者：

LEFRERE, JJ

MARIOTTI, M

WATTEL, E

LEFRERE, F

INCHAUSPE, G

COSTAGLIOLA, D

PRINCE, A

机构：

[1] NEW YORK BLOOD CTR,NEW YORK,NY 10021

[2] INSERM,U263,F-75005 PARIS,FRANCE

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1992年 / 82卷 / 02期

关键词：

D O I：

10.1111/j.1365-2141.1992.tb06446.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The proviral copy (PVC) number in peripheral blood mononuclear cells (PBMCs) of human immunodeficiency virus (HIV)-infected individuals was measured by a quantitative polymerase chain reaction (PCR) assay to determine over time the relation between the viral load and the evolution towards the disease in HIV-infected people: 67 anti-HIV-1 positive individuals (60 stage II/III, 7 stage IV) were studied. The mean PVC number per 1.5 x 10(5) PBMCs in stage II/III individuals (14.4+/-14.2) and in stage IV individuals (32.2+/-22.9) was significantly different (P < 0.02). PVC number was inversely correlated to the CD4 lymphocyte count (P < 0.01). In the logistic regression, the PVC number was a better marker of evolution towards the disease than the CD4 lymphocyte count. The mean proportion of HIV-infected PBMCs in stage IV individuals and in stage II/III individuals was 1/4606 and 1/10714, respectively.

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页码：467 / 471

页数：5

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