COCAINE INDUCES RAPID LOSS OF INTRACELLULAR FREE MG-2+ IN CEREBRAL VASCULAR SMOOTH-MUSCLE CELLS

被引：22

作者：

ALTURA, BM

ZHANG, A

CHENG, TPO

ALTURA, BT

机构：

[1] SUNY HLTH SCI CTR BROOKLYN,DEPT PHYSIOL,450 CLARKSON AVE,BROOKLYN,NY 11203

[2] SUNY HLTH SCI CTR BROOKLYN,DEPT ANAT & CELL BIOL,BROOKLYN,NY 11203

[3] SUNY HLTH SCI CTR BROOKLYN,DEPT MED,BROOKLYN,NY 11203

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1993年 / 246卷 / 03期

关键词：

MG-2+ (CYTOSOLIC; FREE); COCAINE STROKES; MAG-FURA-2;

D O I：

10.1016/0922-4106(93)90046-C

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Acute exposure of cultured canine cerebral vascular smooth muscle cells to low concentrations of cocaine HCl (10(-9) to (10(-7) M) resulted in significant, rapid (1 min) loss of intracellular free Mg ions ([Mg2+]i); these reductions (12-25%) in [Mg2+]i were reversible upon exposure to normal, Mg2+-containing physiological salt solution. These findings help to provide a rational basis for why cocaine can result in cerebrovasospasm and stroke.

引用

页码：299 / 301

页数：3

共 8 条

[1] COCAINE INDUCES INTRACELLULAR FREE MG DEFICITS, ISCHEMIA AND STROKE AS OBSERVED BY INVIVO P-31-NMR OF THE BRAIN [J].