THE SYNTHESIS OF A C-1-C-8 LACTONE FRAGMENT OF DISCODERMOLIDE

被引:42
作者
GOLEC, JMC
JONES, SD
机构
[1] Roussel Laboratories Ltd., Covingham Swindon, Wiltshire SN3 5BZ England, Kingfisher Drive
关键词
D O I
10.1016/S0040-4039(00)61479-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The assymetric synthesis of a fragment corresponding to the C-1-C-8 region of the immunosuppressant dicodermolide is reported. A trihydroxylactone of defined absolute stereochemistry is also prepared. This compound is a potential reductive ozonolysis product of discodermolide and may aid the determination of the absolute stereochemistry or the natural product
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页码:8159 / 8162
页数:4
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