CLINICAL-SIGNIFICANCE OF ANTINUCLEAR ANTIBODIES IN JAPANESE PATIENTS WITH SYSTEMIC-SCLEROSIS

被引：18

作者：

IGARASHI, A ^{[1
]}

TAKEHARA, K ^{[1
]}

SOMA, Y ^{[1
]}

KIKUCHI, K ^{[1
]}

ISHIBASHI, Y ^{[1
]}

机构：

[1] UNIV TOKYO, BRANCH HOSP,FAC MED,DEPT DERMATOL, 3-28-6 MEJIRODAI,BUNKYO, TOKYO 113, JAPAN

来源：

DERMATOLOGICA | 1990年 / 180卷 / 03期

关键词：

anti-nRNP antibody; anti-Scl-70; antibody; anticentromere antibody; antinuclear antibodies; systemic sclerosis;

D O I：

10.1159/000248013

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Clinical significance of specific antinuclear antibodies (ANA) in Japanese patients with systemic sclerosis was studied. The patients with systemic sclerosis were classified into four groups according to ANA: (1) anticentromere antibody-positive; (2) anti-Scl-70-antibody-positive; (3) anti-nRNP antibody-positive, and (4) others. The mean score (the number of positive signs in six selected specific signs) of the patients with anti-Scl-70 antibody was significantly higher than those of the other three groups. More frequent contracture of phalanges in the patients with anti-Scl-70 antibody, less diffuse pigmentation in the patients with anti-nRNP antibody, and less pulmonary fibrosis in the patients with anticentromere antibody were revealed. As shown above, the detection of specific ANA in systemic sclerosis is clinically important.

引用

页码：136 / 140

页数：5

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