PORPHYRIN-CHLORAMBUCIL CONJUGATES - SYNTHESIS AND LIGHT-INDUCED NUCLEASE ACTIVITY

被引：19

作者：

MEHTA, G ^{[1
]}

SAMBAIAH, T ^{[1
]}

MAIYA, BG ^{[1
]}

SIRISH, M ^{[1
]}

DATTAGUPTA, A ^{[1
]}

机构：

[1] UNIV HYDERABAD,SCH LIFE SCI,HYDERABAD 500134,ANDHRA PRADESH,INDIA

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(00)73151-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several porphyrin-chlorambucil hybrid molecules have been synthesized and their light induced DNA cleavage activity studied.

引用

页码：4201 / 4204

页数：4

共 7 条

[1]

BROWN SB, 1993, CHEM BRIT, V29, P955

[2]

BROWN SB, 1992, PHOTODYNAMIC THERAPY

[3] CYTO-TOXIC HYBRID MOLECULES METALLOPORPHYRIN-ELLIPTICINE HAVING A HIGH-AFFINITY FOR DNA [J].

DING, L ;

ETEMADMOGHADAM, G ;

CROS, S ;

AUCLAIR, C ;

MEUNIER, B .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (22) :1711-1713

[4] SYNTHESIS OF HYBRID METALLOPORPHYRIN-ELLIPTICINE MOLECULES [J].

ETEMADMOGHADAM, G ;

DING, L ;

TADJ, F ;

MEUNIER, B .

TETRAHEDRON, 1989, 45 (09) :2641-2648

[5]

HASHIMOTO Y, 1983, TETRAHEDRON LETT, P1523

[6] BLEOMYCIN MODELS - HEMIN ACRIDINES WHICH BIND TO DNA AND CAUSE OXYGEN-DEPENDENT SCISSION [J].

LOWN, JW ;

JOSHUA, AV .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1982, (22) :1298-1300

[7] SYNTHESIS AND NUCLEASE ACTIVITY OF SOME PORPHYRIN ACRIDONE HYBRID MOLECULES [J].

MEHTA, G ;

SAMBAIAH, T ;

MAIYA, BG ;

SIRISH, M ;

CHATTERJEE, D .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1993, (22) :2667-2669

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