ANTICANCER AGENTS .19. SYNTHESIS OF THE REDUCED A-UNIT (CI) OF THE ANTITUMOR ANTIBIOTIC CC-1065

被引：25

作者：

TIETZE, LF

GROTE, T

机构：

[1] Institut für Organische Chemie, Universität Göttingen, Göttingen, D-37077

来源：

CHEMISCHE BERICHTE | 1993年 / 126卷 / 12期

关键词：

CC-1065; ANTITUMOR ANTIBIOTICS; ZIRCONOCENE-INDUCED CYCLIZATION; INDOLINES;

D O I：

10.1002/cber.19931261224

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of the reduced A-unit 2 (CI) of CC-1065 (1) using a metal-mediated cyclisation is described. Reaction of N-allyl-N-benzylaniline 4b and zirconocene(methyl) chloride with tert-BuLi leads via a zirconocene-stabilized benzyne complex 5 to the 3,4-difunctionalized indoline derivative 7, which was converted in five steps into 2.

引用

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页码：2733 / 2737

页数：5

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