EVALUATION OF THE MUTAGENICITY OF PAN-MASALA, A CHEWING SUBSTITUTE WIDELY USED IN INDIA

被引：15

作者：

BAGWE, AN

GANU, UK

GOKHALE, SV

BHISEY, RA

机构：

[1] TATA MEM HOSP,CANC RES INST,GENOTOX UNIT,BOMBAY 400012,INDIA

[2] TATA MEM HOSP,CANC RES INST,PHARMACOKINET & DRUG TARGETING UNIT,BOMBAY 400012,INDIA

来源：

MUTATION RESEARCH | 1990年 / 241卷 / 04期

关键词：

'Pan masala'; Ames assay; Mutagenicity; Polar and non-polar extracts;

D O I：

10.1016/0165-1218(90)90064-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mutagenicity of polar and non-polar extracts of a popular brand of 'pan masala' was examined using the Salmonella/mammalian microsome test (Ames assay) and 2 tester strains of Salmonella typhimurium, TA98 and TA100. These extracts were also subjected to pretreatment with sodium nitrite at acidic pH, to simulate conditions for endogenous nitrosation. The equeous, aqueous: ethanolic and chloroform extracts as well as their nitrosated mixtures were non-mutagenic in the Ames assay, in the presence and absence of metabolic activation. Only the ethanolic extract elicited a weak mutagenic response in strain TA98 without metabolic activation demonstrating the presence of direct-acting frameshift mutagens in 'pan masala'. © 1990.

引用

页码：349 / 354

页数：6

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