DOMAINS AND THE HINGE REGION OF AN IMMUNOGLOBULIN HEAVY-CHAIN ARE ENCODED IN SEPARATE DNA SEGMENTS

被引：282

作者：

SAKANO, H

ROGERS, JH

HUPPI, K

BRACK, C

TRAUNECKER, A

MAKI, R

WALL, R

TONEGAWA, S

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,INST MOLEC BIOL,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90024

来源：

NATURE | 1979年 / 277卷 / 5698期

关键词：

D O I：

10.1038/277627a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A 6.8-kilobase DNA fragment containing the sequence coding for the constant region of the mouse immunoglobulin γ1 heavy chain was cloned from total cellular DNA. Electron microscopic and nucleotide sequencing studies showed that the three protein domains and the hinge region are encoded in separate DNA segments. © 1979 Nature Publishing Group.

引用

页码：627 / 633

页数：7

共 44 条

[1] MOLECULAR ANALYSIS OF SPONTANEOUS SOMATIC MUTANTS
ADETUGBO, K
MILSTEIN, C
SECHER, DS
[J]. NATURE, 1977, 265 (5592) : 299 - 304
[2] ADETUGBO K, 1978, J BIOL CHEM, V253, P6068
[3] BENNICH H, 1974, PROGR IMMUNOLOGY 2, V1, P49
[4] SCREENING GAMMAGT RECOMBINANT CLONES BY HYBRIDIZATION TO SINGLE PLAQUES INSITU
BENTON, WD
DAVIS, RW
[J]. SCIENCE, 1977, 196 (4286) : 180 - 182
[5] SPLICED SEGMENTS AT 5' TERMINUS OF ADENOVIRUS 2 LATE MESSENGER-RNA
BERGET, SM
MOORE, C
SHARP, PA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (08) : 3171 - 3175
[6] SEQUENCES OF MOUSE IMMUNOGLOBULIN LIGHT CHAIN GENES BEFORE AND AFTER SOMATIC CHANGES
BERNARD, O
HOZUMI, N
TONEGAWA, S
[J]. CELL, 1978, 15 (04) : 1133 - 1144
[7] VARIABLE AND CONSTANT PARTS OF IMMUNOGLOBULIN LIGHT CHAIN GENE OF A MOUSE MYELOMA CELL ARE 1250 NON-TRANSLATED BASES APART
BRACK, C
TONEGAWA, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) : 5652 - 5656
[8] COMPLETE IMMUNOGLOBULIN GENE IS CREATED BY SOMATIC RECOMBINATION
BRACK, C
HIRAMA, M
LENHARDSCHULLER, R
TONEGAWA, S
[J]. CELL, 1978, 15 (01) : 1 - 14
[9] OVALBUMIN GENE IS SPLIT IN CHICKEN DNA
BREATHNACH, R
MANDEL, JL
CHAMBON, P
[J]. NATURE, 1977, 270 (5635) : 314 - 319
[10] OVALBUMIN GENE - EVIDENCE FOR A LEADER SEQUENCE IN MESSENGER-RNA AND DNA SEQUENCES AT EXON-INTRON BOUNDARIES
BREATHNACH, R
BENOIST, C
OHARE, K
GANNON, F
CHAMBON, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (10) : 4853 - 4857

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