ASYMMETRIC INDUCTION IN ACYCLIC RADICAL REACTIONS - ENANTIOSELECTIVE SYNTHESES OF (S)-2-DEUTERIOGLYCINE AND (R)-2-DEUTERIOGLYCINE

被引：20

作者：

HAMON, DPG

MASSYWESTROPP, RA

RAZZINO, P

机构：

[1] Department of Organic Chemistry, University of Adelaide, Adelaide, SA 5001

来源：

TETRAHEDRON | 1993年 / 49卷 / 29期

关键词：

D O I：

10.1016/S0040-4020(01)80156-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The (-)-8-phenylmenthol esters of N-Boc-glycine and N-BOC-2,2-dideuterioglycine were brominated with N-bromosuccinimide and the bromo compounds were reduced with tri-n-butyldeuteriostannane and tri-n-butylstannane respectively, to give the chiral glycine derivatives in 90% optical yield. Hydrolysis yielded the amino acid without racemisation.

引用

页码：6419 / 6428

页数：10

共 18 条

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