ENDOTOXIN-INDUCED PRODUCTION OF INTERLEUKIN-6 IS ENHANCED BY VITAMIN-E-DEFICIENCY AND REDUCED BY BLACK TEA EXTRACT

被引：24

作者：

AMARAKOON, AMT ^{[1
]}

TAPPIA, PS ^{[1
]}

GRIMBLE, RF ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON, DEPT HUMAN NUTR, SOUTHAMPTON SO16 7PX, HANTS, ENGLAND

来源：

INFLAMMATION RESEARCH | 1995年 / 44卷 / 07期

关键词：

ENDOTOXIN; INTERLEUKIN-6; VITAMIN-E; BLACK TEA;

D O I：

10.1007/BF02032573

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Studies were performed to investigate the effect of a polyphenol rich extract from black tea and vitamin E on bacterial lipopolysaccharide (endotoxin) induced IL-6 production, alterations in liver glutathione and antioxidant acute phase protein (caeruloplasmin) concentration, in rats fed on a synthetic diet for 21 days. In the vitamin E sufficient group a significantly lower IL-6 concentration than in vitamin E deficient animals was observed. Addition of tea extract to the diet produced a similar reduction in IL-6, but no synergism occurred in the presence of both vitamin E and tea extract. However, a significantly lower caeruloplasmin and a significantly higher liver glutathione concentration was observed in rats fed both substances. It is suggested that consideration of dietary components which alter antioxidant/oxidant status may contribute towards treatment of inflammatory/autoimmune diseases.

引用

页码：301 / 305

页数：5

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