SUGAR-DNA MOLECULAR RECOGNITION - SPECIFIC INTERACTION OF ALPHA-1,4-GLUCOPYRANOSE CHAINS WITH DNA IN THE MINOR-GROOVE

被引：6

作者：

KRISHNA, AG

BALASUBRAMANIAN, D

GANESH, KN

机构：

[1] NATL CHEM LAB,DIV ORGAN CHEM,POONA 411008,MAHARASHTRA,INDIA

[2] CTR CELLULAR & MOLEC BIOL,HYDERABAD 500047,ANDHRA PRADESH,INDIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 202卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.1913

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

alpha(1,4) glucopyranose chains (dextrins) are shown to interact with DNA via hydrophobic interactions from the minor groove side, while alpha(1,6) dextrans do not bind DNA. The observed specific alpha(1,4) linked sugar-DNA interactions may have importance in recognition of DNA by ene-diyne class of antibiotics via their saccharide units which have mostly alpha(1,4) linkages. (C) 1994 Academic Press, Inc.

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页码：204 / 210

页数：7

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