IMPORTANCE OF DYNAMIC PROPERTIES OF IDIOTOPES IN INTERACTIONS WITH ANTI-ID ANTIBODIES

被引：12

作者：

VOSS, EW

WEIDNER, KM

DENZIN, LK

机构：

[1] Department of Microbiology, University of Illinois, Urbana, IL, 61801, 131 Burrill Hall

来源：

IMMUNOLOGICAL INVESTIGATIONS | 1992年 / 21卷 / 01期

关键词：

D O I：

10.3109/08820139209069364

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The concept of fluctuating conformational substates in equilibrium characterizing variable-regions of immunoglobulin idiotypes is discussed in terms of the dynamic properties of idiotopes and their stabilization upon interactions with anti-idiotope antibodies. Uniquely, polyclonal anti-Id antibodies are viewed in cooperative immobilizing interactions with the idiotopes thereby facilitating formation of stable complexes.

引用

页码：71 / 83

页数：13

共 39 条

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[2]

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