IMPORTANCE OF DYNAMIC PROPERTIES OF IDIOTOPES IN INTERACTIONS WITH ANTI-ID ANTIBODIES

被引：12

作者：

VOSS, EW

WEIDNER, KM

DENZIN, LK

机构：

[1] Department of Microbiology, University of Illinois, Urbana, IL, 61801, 131 Burrill Hall

来源：

IMMUNOLOGICAL INVESTIGATIONS | 1992年 / 21卷 / 01期

关键词：

D O I：

10.3109/08820139209069364

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The concept of fluctuating conformational substates in equilibrium characterizing variable-regions of immunoglobulin idiotypes is discussed in terms of the dynamic properties of idiotopes and their stabilization upon interactions with anti-idiotope antibodies. Uniquely, polyclonal anti-Id antibodies are viewed in cooperative immobilizing interactions with the idiotopes thereby facilitating formation of stable complexes.

引用

收藏

页码：71 / 83

页数：13

相关论文

共 39 条

[31]

RINFRET A, 1990, J IMMUNOL, V145, P925

[32] AMINO-ACID-SEQUENCE OF HOMOGENEOUS ANTIBODIES TO DEXTRAN AND DNA REARRANGEMENTS IN HEAVY-CHAIN V-REGION GENE SEGMENTS [J].

SCHILLING, J ;

CLEVINGER, B ;

DAVIE, JM ;

HOOD, L .

NATURE, 1980, 283 (5742) :35-40

[33] DUAL CONFORMATIONS OF AN IMMUNOGLOBULIN LIGHT-CHAIN DIMER - HETEROGENEITY OF ANTIGEN-SPECIFICITY AND IDIOTOPE PROFILE MAY RESULT FROM MULTIPLE VARIABLE-DOMAIN INTERACTION MECHANISMS [J].

STEVENS, FJ ;

CHANG, CH ;

SCHIFFER, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (18) :6895-6899

[34]

STEVENSON GT, 1989, METHOD ENZYMOL, V178, P341

[35] 3-DIMENSIONAL STRUCTURE OF MURINE ANTI-PARA-AZOPHENYLARSONATE FAB-36-71 .2. STRUCTURAL BASIS OF HAPTEN BINDING AND IDIOTYPY [J].

STRONG, RK ;

PETSKO, GA ;

SHARON, J ;

MARGOLIES, MN .

BIOCHEMISTRY, 1991, 30 (15) :3749-3757

[36] FUNCTIONAL AND STRUCTURAL IMPLICATIONS OF VARIABLE REGION IMMUNOGLOBULIN DYNAMIC STATES [J].

VOSS, EW ;

DOMBRINKKURTZMAN, MA ;

MIKLASZ, SD .

IMMUNOLOGICAL INVESTIGATIONS, 1988, 17 (01) :25-39

[37] ANTI-METATYPE ANTIBODY REACTIVITY - A MODEL FOR T-CELL RECEPTOR RECOGNITION [J].

VOSS, EW .

IMMUNOLOGY TODAY, 1990, 11 (10) :355-357

[38] POLYCLONAL ANTIBODIES SPECIFIC FOR LIGANDED ACTIVE-SITE (METATYPE) OF A HIGH-AFFINITY ANTI-HAPTEN MONOCLONAL-ANTIBODY [J].

VOSS, EW ;

MIKLASZ, SD ;

PETROSSIAN, A ;

DOMBRINKKURTZMAN, MA .

MOLECULAR IMMUNOLOGY, 1988, 25 (08) :751-759

[39]

WEIDNER KM, 1991, J BIOL CHEM, V266, P2513

← 1 2 3 4 →