3-(2-CARBOXYPIPERAZIN-4-YL)PROPYL-1-PHOSPHONIC ACID DECREASES NMDA RECEPTOR MESSENGER-RNA

被引：11

作者：

LESCH, KP ^{[1
]}

AULAKH, CS ^{[1
]}

WOLOZIN, BL ^{[1
]}

HILL, JL ^{[1
]}

MURPHY, DL ^{[1
]}

机构：

[1] NIMH,CTR CLIN,CLIN SCI LAB,CLIN NEUROPHARMACOL SECT,BETHESDA,MD 20892

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1992年 / 227卷 / 01期

关键词：

NMDA RECEPTOR MESSENGER RNA; NMDA RECEPTOR ANTAGONISTS; POLYMERASE CHAIN REACTION;

D O I：

10.1016/0922-4106(92)90151-K

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Expression of the N-methyl-D-aspartate receptor gene during long-term administration of competitive and non-competitive NMDA antagonists was studied in rat brain using antisense cRNA transcribed from reverse transcriptase-polymerase chain reaction (RT-PCR)-generated rat NMDA receptor cDNA. Unlike non-competitive antagonists, 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) markedly decreased NMDA receptor mRNA steady-state concentrations in frontal cortex and hippocampus. Our results are consistent with a regulation of the NMDA receptor at the level of gene expression.

引用

页码：109 / 111

页数：3

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