CHRONIC ADMINISTRATION OF MK-801 AND THE NMDA RECEPTOR - FURTHER EVIDENCE FOR REDUCED SENSITIVITY OF THE PRIMARY ACCEPTOR SITE FROM STUDIES WITH THE CORTICAL WEDGE PREPARATION

被引：19

作者：

BEART, PM

LODGE, D

机构：

[1] UNIV LONDON ROYAL VET COLL,ROYAL COLL ST,LONDON NW1 0TU,ENGLAND

[2] UNIV MELBOURNE,AUSTIN HOSP,PHARMACOL CLIN,HEIDELBERG,VIC 3084,AUSTRALIA

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1990年 / 42卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1111/j.2042-7158.1990.tb05426.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Abstract— Cortical slices removed from rats pre‐treated with MK‐901 0.5 mg kg−1 twice a day for 7 days had reduced responses to N‐methyl‐D‐aspartate (NMDA) relative to quisqualate and glutamate compared with control animals. Potencies of competitive (CPMP) and non‐competitive (ketamine) NMDA antagonists appeared unchanged. These changes are consistent with a reduced density of NMDA receptors. 1990 Royal Pharmaceutical Society of Great Britain

引用

页码：354 / 355

页数：2

共 5 条

[1]

DAVIES SN, 1988, J PHYSIOL-LONDON, V406, pP15

[2] DIFFERENCES IN RESULTS FROM INVIVO AND INVITRO STUDIES ON THE USE-DEPENDENCY OF N-METHYLASPARTATE ANTAGONISM BY MK-801 AND OTHER PHENCYCLIDINE RECEPTOR LIGANDS [J].