THE PITUITARY-HORMONES ARGININE VASOPRESSIN-NEUROPHYSIN-II AND OXYTOCIN-NEUROPHYSIN-I SHOW CLOSE LINKAGE WITH INTERLEUKIN-1 ON MOUSE CHROMOSOME-2

被引：26

作者：

MARINI, JC

NELSON, KK

BATTEY, J

SIRACUSA, LD

机构：

[1] JEFFERSON CANC INST,DEPT MICROBIOL & IMMUNOL,233 S 10TH ST,PHILADELPHIA,PA 19107

[2] NCI,BIOL CHEM LAB,BETHESDA,MD 20892

来源：

GENOMICS | 1993年 / 15卷 / 01期

关键词：

D O I：

10.1006/geno.1993.1034

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Arginine vasopressin (AVP) and oxytocin (OXT) are posterior pituitary hormones. Avp is involved in fluid homeostasis, while OXT is involved in lactation and parturition. AVP is derived from a larger precursor, prepro- arginine- vasopressin- neurophysin II (prepro-AVP-NP II; AVP), and is physically linked to prepro-oxytocin-neurophysin I (prepro-OXT-NP I; OXT). The genes for AVP and OXT are separated by only 12 kb of DNA in humans, whereas in the mouse 3.5 kb of intergenic sequence lies between Avp and Oxt. Interspecific backcross analysis has now been used to map the Avp/Oxt complex to chromosome 2 in the mouse. This map position confirms and extends the known region of linkage conservation between mouse chromosome 2 and human chromosome 20. © 1993 Academic Press, Inc.

引用

页码：200 / 202

页数：3

共 16 条

[1] A MISSENSE MUTATION IN THE VASOPRESSIN-NEUROPHYSIN PRECURSOR GENE COSEGREGATES WITH HUMAN AUTOSOMAL DOMINANT NEUROHYPOPHYSEAL DIABETES-INSIPIDUS [J].