NK1 RECEPTOR EXPRESSION BY CHOLINERGIC INTERNEURONS IN HUMAN STRIATUM

被引：33

作者：

AUBRY, JM

LUNDSTROM, K

KAWASHIMA, E

AYALA, G

SCHULZ, P

BARTANUSZ, V

KISS, JZ

机构：

[1] INST UNIV PSYCHIAT GENEVA,DEPT PSYCHIAT,GENEVA,SWITZERLAND

[2] GLAXO INST MOLEC BIOL SA,GENEVA,SWITZERLAND

[3] UNIV GENEVA,SCH MED,CMU,DEPT MORPHOL,CH-1211 GENEVA 4,SWITZERLAND

来源：

NEUROREPORT | 1994年 / 5卷 / 13期

关键词：

STRIATUM; INTERNEURON; CHOLINE ACETYLTRANSFERASE; NK1; RECEPTOR; MESSENGER-RNA; IN SITU HYBRIDIZATION; POLYMERASE CHAIN REACTION;

D O I：

10.1097/00001756-199408150-00014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

NEUROKININ-1 (NK1) receptor expression in human striatum was analysed using the polymerase chain reaction. To determine whether cholinergic interneurones express this receptor, in situ hybridization histochemistry was then applied to caudate nucleus and putamen. Radioactive oligonucleotide probes specific for choline acetyltransferase (ChAT) and NK1 receptor mRNA were used on adjacent cryostat sections. All of the 160 identified neurones positive for ChAT were also labelled for NK1 receptor. Moreover, in the caudate nucleus, NK1 receptor mRNA was detected in a population of large neurones that were not cholinergic. These results are consistent with the hypothesis that NK1 receptor-mediated mechanisms are involved in the function of cholinergic interneurones. This might be relevant to pharmacological or pathophysiological situations where substance P inputs are modified.

引用

页码：1597 / 1600

页数：4

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