EXPRESSION OF C-FOS AND C-MYC PROTO-ONCOGENES IN HUMAN ADRENAL PHEOCHROMOCYTOMAS

被引:18
作者
GOTO, K
OGO, A
YANASE, T
HAJI, M
OHASHI, M
NAWATA, H
机构
[1] Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka
关键词
D O I
10.1210/jcem-70-2-353
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We examined c-fos and c-myc expressions in pheochromocytoma tissues from six patients. All samples contained c-fos and c-myc transcripts, whereas mRNA from bovine adrenal medulla, as a control, did not contain these transcripts at detectable levels. Southern blot analysis revealed no amplification and no rearrangement of c-fos and c-myc genes. We also examined the gene expression of insulin-like growth factor-II (IGF-II), a mitogen for rat pheochromocytoma cells exerted by autocrine or paracrine fashion. All samples from the pheochromocytomas contained IGF-II transcripts as well as c-fos and cmyc transcripts. The constitutive expressions of c-fos and c-myc genes may be interpreted to mean that pheochromocytoma is in a state of growth stimulation in vivo by growth factors, including IGF-II. © 1990 by The Endocrine Society.
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页码:353 / 357
页数:5
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