A DELETION AND A REARRANGEMENT DISTINGUISH BETWEEN THE INTRACISTERNAL A-PARTICLE OF HOX-2.4 AND THAT OF INTERLEUKIN-3 IN THE SAME LEUKEMIC-CELLS

被引：14

作者：

BENDAVID, L ^{[1
]}

ABERDAM, D ^{[1
]}

SACHS, L ^{[1
]}

BLATT, C ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT MOLEC GENET & VIROL,IL-76100 REHOVOT,ISRAEL

来源：

VIROLOGY | 1991年 / 182卷 / 01期

关键词：

D O I：

10.1016/0042-6822(91)90686-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two intracisternal A-particle (IAP) insertions have been identified in WEHI-3B myeloid leukemic cells, one at the interleukin-3 (IL-3) gene and another at the homeobox gene Hox-2.4. In contrast to the 5-kb IL-3-IAP, the Hox-2.4-IAP is only 2.1 kb in size and contains a rearrangement. The homology throughout the remaining sequences suggests that both IAPs originated from a common progenitor molecule. Both proviral insertions have resulted in transcriptional activation of the adjacent genes, which appears to be a significant step in the leukemogenic process in these leukemic cells. © 1991.

引用

页码：382 / 387

页数：6

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