INTERLEUKINS - BIOLOGICAL PROPERTIES AND THERAPEUTIC POTENTIAL

被引：28

作者：

ELMSLIE, RE

DOW, SW

OGILVIE, GK

机构：

[1] Pathology Colorado State University, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, Colorado

来源：

JOURNAL OF VETERINARY INTERNAL MEDICINE | 1991年 / 5卷 / 05期

关键词：

D O I：

10.1111/j.1939-1676.1991.tb03135.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Interleukins are biologically active glycoproteins derived primarily from activated lymphocytes and macrophages. Tremendous insight into the biochemical and biological properties of interleukins has been gained with advances in recombinant DNA technology, protein purification, and cell-culture techniques. The biological properties of interleukins include induction of T-lymphocyte activation and proliferation, augmentation of neutrophil, macrophage, and T-lymphocyte cytotoxicity, and promotion of B lymphocyte and multilineage bone marrow stem-cell precursor growth and differentiation. Interleukins may play a role in the pathogenesis of several important diseases. Interleukin therapy is likely to play an important role in the treatment of cancer, infectious diseases, and immunodeficiency syndromes.

引用

页码：283 / 293

页数：11

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