SUPPRESSION OF DYSKINESIAS IN ADVANCED PARKINSONS-DISEASE .2. INCREASING DAILY CLOZAPINE DOSES SUPPRESS DYSKINESIAS AND IMPROVE PARKINSONISM SYMPTOMS

被引：100

作者：

BENNETT, JP

LANDOW, ER

SCHUH, LA

机构：

[1] UNIV VIRGINIA,SCH MED,DEPT BEHAV MED & PSYCHIAT,CHARLOTTESVILLE,VA 22908

[2] UNIV VIRGINIA,SCH MED,DEPT PHARMACOL,CHARLOTTESVILLE,VA 22908

来源：

NEUROLOGY | 1993年 / 43卷 / 08期

关键词：

D O I：

10.1212/WNL.43.8.1551

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We gave increasing daily doses of clozapine to six patients with advanced Parkinson's disease (PD) and levodopa-induced dyskinesias. Clozapine reduced the daily dyskinesia time five-fold, increased ''on'' time eight-fold, and doubled the serum [DOPA] producing half-maximal dyskinesia. Parkinsonism scores after overnight DOPA withdrawal improved with increasing daily clozapine intake, and there was no clozapine dose-related shift in levodopa dose response for relief of parkinsonism. Patients experienced sedation, sialorrhea, and orthostatic hypotension. Clozapine appears to be an effective agent for suppression of levodopa-induced dyskinesias in PD.

引用

页码：1551 / 1555

页数：5

共 17 条

[1] EVIDENCE FOR DIFFERENT STATES OF THE DOPAMINE D1 RECEPTOR - CLOZAPINE AND FLUPERLAPINE MAY PREFERENTIALLY LABEL AN ADENYLATE CYCLASE-COUPLED STATE OF THE D1-RECEPTOR [J].