A NOVEL METHOD TO FABRICATE BIOABSORBABLE SCAFFOLDS

被引：480

作者：

WHANG, K

THOMAS, CH

HEALY, KE

NUBER, G

机构：

[1] NORTHWESTERN UNIV, SCH DENT, DEPT BIOL MAT, CHICAGO, IL 60611 USA

[2] NORTHWESTERN UNIV, MCCORMICK SCH ENGN, DEPT BIOMED ENGN, EVANSTON, IL 60208 USA

[3] NORTHWESTERN UNIV, SCH MED, DEPT ORTHOPED SURG, CHICAGO, IL USA

来源：

POLYMER | 1995年 / 36卷 / 04期

关键词：

TISSUE ENGINEERING; BIOABSORBABLE POLYMERS; EMULSION PROCESSING;

D O I：

10.1016/0032-3861(95)93115-3

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

An emulsion freeze-drying method for processing porous biodegradable copolymers of polylactic and polyglycolic acid (PLGA) scaffolds was developed. Scaffold porosity and pore sizes were measured using mercury porosimetry. Foams with porosity in the range 91-95%, median pore diameters ranging from 13 to 35 mu m (with larger pore diameters greater than 200 mu m), and specific pore area in the range 58-102 m(2) g(-1) were made by varying processing parameters such as water volume fraction, polymer weight percentage and polymer molecular weight. These scaffolds may find applications as structures that facilitate either tissue regeneration or repair during reconstructive operations.

引用

页码：837 / 842

页数：6

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