CONTROLLED RELEASE OF INTERLEUKIN-2 FROM BIODEGRADABLE MICROSPHERES

被引：74

作者：

HORA, MS ^{[1
]}

RANA, RK ^{[1
]}

NUNBERG, JH ^{[1
]}

TICE, TR ^{[1
]}

GILLEY, RM ^{[1
]}

HUDSON, ME ^{[1
]}

机构：

[1] SO RES INST,BIRMINGHAM,AL 35205

来源：

BIO-TECHNOLOGY | 1990年 / 8卷 / 08期

关键词：

D O I：

10.1038/nbt0890-755

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have evaluated the use of biodegradable poly(DL-lactide-co-glycolide) microspheres for the controlled release of inter-leukin-2 (IL-2) and its modified forms: succinyl IL-2 (SIL-2) and polyethylene glycol-modified IL-2 (PEG IL-2). We show that a microsphere formulation can be prepared from PEG IL-2 using HSA as an excipient which, after an initial burst, releases 2-3% PEG IL-2 per day in a bioac-tive form continuously over a 20- to 30-day period. © 1990 Nature Publishing Group.

引用

收藏

页码：755 / 758

页数：4

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