THE EFFECT OF DIETARY CHANGE ON INVITRO ERYTHROCYTE HEMOLYSIS, SKIN-LESIONS AND ALOPECIA IN COMMON MARMOSETS (CALLITHRIX-JACCHUS)

被引：8

作者：

GHEBREMESKEL, K ^{[1
]}

HARBIGE, LS ^{[1
]}

WILLIAMS, G ^{[1
]}

CRAWFORD, MA ^{[1
]}

HAWKEY, C ^{[1
]}

机构：

[1] ZOOL SOC LONDON,INST ZOOL,LONDON NW1 4RY,ENGLAND

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-PHYSIOLOGY | 1991年 / 100卷 / 04期

关键词：

VITAMIN-E-DEFICIENCY; ESSENTIAL FATTY-ACID; SAGUINUS-LABIATUS; PLASMA CHOLESTEROL; HYDROGEN-PEROXIDE; SQUIRREL-MONKEYS; HEMOLYTIC-ANEMIA; LIPIDS; SUSCEPTIBILITY; TOCOPHEROL;

D O I：

10.1016/0300-9629(91)90310-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. The effect of dietary change on common marmosets (Callithrix jacchus) exhibiting high in vitro erythrocyte haemolysis, skin lesions and alopecia was investigated. 2. The experimental diet was low in lipid, high in vitamin E and was devoid of n-3 long chain polyunsaturated fatty acids. 3. There were significant increases in the concentrations of plasma alpha-tocopherol (vitamin E) (P < 0.05), all-trans retinol (vitamin A) (P < 0.001) and total lipid (P < 0.025), and a reduction in fibrinogen (P < 0.02) concentration and neutrophil count (P < 0.02). 4. Moreover, the mean in vitro erythrocyte haemolysis declined from an initial value of 64% to less than 2%, and there was a regression of skin lesions and alopecia with complete fur regrowth. 5. The amelioration of the conditions appear to be due to high circulating vitamin E which provided protection against oxidative stress, and the correction of membrane n-6:n-3 balance.

引用

页码：891 / 896

页数：6

共 48 条

[1]

Ausman L M., 1985, Handbook of squirrel monkey research, P349

[2] VITAMIN-E-DEFICIENCY ANEMIA IN OLD AND NEW WORLD MONKEYS [J].