KINAMYCIN BIOSYNTHESIS - SYNTHESIS, DETECTION, AND INCORPORATION OF KINOBSCURINONE, A BENZOL[B]FLUORENONE

被引：55

作者：

GOULD, SJ

MELVILLE, CR

机构：

[1] Department of Chemistry Oregon State University, Corvallis

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 01期

关键词：

D O I：

10.1016/0960-894X(94)00457-Q

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The kinamycin antibiotics, derived from a benz[a]anthraquinone precursor, were recently shown to be 5-diazobenzo[b]fluorene quinones. A 5-ketobenzo[b]fluorene quinone has been synthesized and shown to be present in Streptomyces murayamaensis fermentations, and a deuterium-labeled sample of this metabolite, kinobscurinone, has been incorporated biosynthetically into kinamycins C and D.

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页码：51 / 54

页数：4

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