HYDROLYSIS OF SYNTHETIC CHROMOGENIC SUBSTRATES BY HIV-1 AND HIV-2 PROTEINASES

被引：64

作者：

PHYLIP, LH

RICHARDS, AD

KAY, J

KONVALINKA, J

STROP, P

BLAHA, I

VELEK, J

KOSTKA, V

RITCHIE, AJ

BROADHURST, AV

FARMERIE, WG

SCARBOROUGH, PE

DUNN, BM

机构：

[1] UNIV COLL CARDIFF, DEPT BIOCHEM, POB 903, CARDIFF CF1 1ST, WALES

[2] CZECHOSLOVAK ACAD SCI, INST ORGAN CHEM & BIOCHEM, FLEMINGOVO NAMESTI 2, CS-16610 PRAGUE 6, CZECHOSLOVAKIA

[3] ROCHE PROD LTD, WELWYN GARDEN CITY AL7 3AY, HERTS, ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 01期

关键词：

D O I：

10.1016/0006-291X(90)91412-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Kinetic constants (Km,kcat) are derived for the hydrolysis of a number of chromogenic peptide substrates by the aspartic proteinase from HIV-2. The effect of systematic replacement of the P2 residue on substrate hydrolysis by HIV-1 and HIV-2 proteinases is examined. © 1990.

引用

页码：439 / 444

页数：6

共 11 条

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