REGULATION OF PROTEOLYSIS AT THE NEUTROPHIL-SUBSTRATE INTERFACE BY SECRETORY LEUKOPROTEASE INHIBITOR

被引:151
作者
RICE, WG [1 ]
WEISS, SJ [1 ]
机构
[1] UNIV MICHIGAN, SIMPSON MEM RES INST, DEPT INTERNAL MED, DIV HEMAT & ONCOL, ANN ARBOR, MI 48109 USA
关键词
D O I
10.1126/science.2371565
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Human neutrophils can initiate the rapid degradation of extracellular matrix macromolecules by localizing the destructive process to sites of cell-substrate contact. Although plasma and its filtrates contain multiple proteinase inhibitors, these inhibitors did not prevent neutrophils from attacking either underlying fibronectin or elastin. However, subjacent substrates could be protected from neutrophils by recombinant secretory leukoprotease inhibitor, a structurally unique serine proteinase inhibitor whose natural counterpart is normally confined to human mucous secretions. The identification of this extravascular proteinase inhibitor as a potent regulator of subjacent proteolysis could lead to the development of a new class of anti-inflammatory therapeutics.
引用
收藏
页码:178 / 181
页数:4
相关论文
共 55 条
[31]  
POWERS J, 1977, BIOCHIM BIOPHYS ACTA, V485, P166
[32]  
REDDY VY, 1989, J BIOL CHEM, V264, P13801
[33]  
RICE WG, UNPUB
[34]   THE ACID-STABLE PROTEINASE-INHIBITOR OF HUMAN MUCOUS SECRETIONS (HUSI-I, ANTILEUKOPROTEASE) - COMPLETE AMINO-ACID-SEQUENCE AS REVEALED BY PROTEIN AND CDNA SEQUENCING AND STRUCTURAL HOMOLOGY TO WHEY PROTEINS AND RED-SEA TURTLE PROTEINASE-INHIBITOR [J].
SEEMULLER, U ;
ARNHOLD, M ;
FRITZ, H ;
WIEDENMANN, K ;
MACHLEIDT, W ;
HEINZEL, R ;
APPELHANS, H ;
GASSEN, HG ;
LOTTSPEICH, F .
FEBS LETTERS, 1986, 199 (01) :43-48
[36]  
SHEPHARD EG, 1989, J IMMUNOL, V143, P2974
[37]  
SIBILLE Y, 1984, AM REV RESPIR DIS, V130, P110
[38]   REPAIR OF PROTEASE-DAMAGED ELASTIN IN NEONATAL RAT AORTIC SMOOTH-MUSCLE CELL-CULTURES [J].
STONE, PJ ;
MORRIS, SM ;
MARTIN, BM ;
MCMAHON, MP ;
FARIS, B ;
FRANZBLAU, C .
JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (05) :1644-1654
[39]   ISOLATION, PROPERTIES, AND COMPLETE AMINO-ACID-SEQUENCE OF HUMAN SECRETORY LEUKOCYTE PROTEASE INHIBITOR, A POTENT INHIBITOR OF LEUKOCYTE ELASTASE [J].
THOMPSON, RC ;
OHLSSON, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (18) :6692-6696
[40]   NONCOMPETITIVE ENZYME-IMMUNOASSAY FOR THE MEASUREMENT OF BRONCHIAL INHIBITOR IN BIOLOGICAL-FLUIDS [J].
TOURNIER, JM ;
JACQUOT, J ;
SADOUL, P ;
BIETH, JG .
ANALYTICAL BIOCHEMISTRY, 1983, 131 (02) :345-350