GLYCOPROTEINS FROM EXPERIMENTAL GRANULATION-TISSUE AND THEIR EFFECTS ON COLLAGEN-SYNTHESIS IN EMBRYONIC CHICK TENDON CELLS

被引：6

作者：

AALTO, M

POTILA, M

KULONEN, E

机构：

[1] Department of Medical Chemistry, University of Turku

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 587卷 / 04期

基金：

英国医学研究理事会;

关键词：

(Embryonic chick); Collagen synthesis; Glycoprotein; Granulation tissue; N-Acetylneuraminic acid; Tendon cell;

D O I：

10.1016/0304-4165(79)90012-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Buffer-soluble and pronase-liberated glycoproteins from experimental granulation tissue were fractionated by gel filtration and DEAE-cellulose chromatography. The age of the granuloma was reflected in the gel filtration pattern. Two glycoproteins were isolated, purified to homogeneity and analyzed for their carbohydrate and amino acid compositions. The collagen synthesis in embryonic chick tendon cells was measured in the presence of these fractions, which were found to be inhibiting even at 10-6 M. These glycoproteins may be significant in the feedback regulation of the development of granulation tissue and fibrosis. © 1979.

引用

页码：606 / 617

页数：12

共 44 条

[21] PREPARATION OF SUBCELLULAR-FRACTIONS FROM GRANULATION-TISSUE BY DENSITY GRADIENT CENTRIFUGATION [J].