DIRECT CHROMATOGRAPHIC RESOLUTION OF RACEMIC AMINOGLUTETHIMIDE AND ITS ACETYLATED METABOLITE USING DIFFERENT CELLULOSE BASED CHIRAL STATIONARY PHASES

被引：20

作者：

ABOULENEIN, HY

ISLAM, MR

机构：

[1] Drug Development Laboratory, Radionuclide and Cyclotron Operations Department, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211

来源：

CHROMATOGRAPHIA | 1990年 / 30卷 / 3-4期

关键词：

Aminoglutethimide; Chiral chromatography; Chiral stationary phases; Enantiomeric separation;

D O I：

10.1007/BF02274552

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Two improved methods for the enantiomeric separation of racemic aminoglutethimide (±AG) and its acetylated metabolite (±AAG) have been developed. Direct liquid chromatographic resolution of the enantiomers of aminoglutethimide and its acetylated metabolite was accomplished using Chiralcel OD and Chiralcel OJ columns without any derivatization. Maximum resolution of 8.87 and 2.23 was obtained for the enantiomers of aminoglutethimide and its acetylated metabolite using a Chiralcel OD column, while maximum resolution of 10.34 and 7.01 was obtained for the enantiomers using a Chiralcel OJ column. Optimization of separation was obtained using different concentration of 2-propanol in hexane as a mobile phase. © 1990 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.

引用

页码：223 / 227

页数：5

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