STRUCTURAL ORGANIZATION AND CHROMOSOMAL MAPPING OF THE HUMAN ID-3 GENE

被引：47

作者：

DEED, RW

HIROSE, T

MITCHELL, ELD

SANTIBANEZKOREF, MF

NORTON, JD

机构：

[1] CHRISTIE HOSP NATL HLTH SERV TRUST,PATERSON INST CANC RES,CRC,DEPT GENE REGULAT,MANCHESTER M20 9BX,LANCS,ENGLAND

[2] CHRISTIE HOSP NATL HLTH SERV TRUST,PATERSON INST CANC RES,CRC,DEPT EXPTL CHEMOTHERAPY,MANCHESTER M20 9BX,LANCS,ENGLAND

[3] CHRISTIE HOSP NATL HLTH SERV TRUST,PATERSON INST CANC RES,CRC,DEPT CANC GENET,MANCHESTER M20 9BX,LANCS,ENGLAND

来源：

GENE | 1994年 / 151卷 / 1-2期

关键词：

HELIX-LOOP-HELIX; TRANSCRIPTION FACTOR; NEGATIVE REGULATOR; EVOLUTIONARY CONSERVATION; HUMAN GENE STRUCTURE; TUMOR CELL; CHROMOSOME TRANSLOCATION;

D O I：

10.1016/0378-1119(94)90676-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The helix-loop-helix (HLH) family of transcription factors plays a central role in the regulation of cell growth, differentiation and tumourigenesis. Members of the Id (inhibitor of DNA binding) class of these nuclear proteins are able to heterodimerise with and thereby antagonise the functions of other transcription factors of this family. We report here on the genomic organisation of the human Id3 (HLH 1R21/heir1) gene. Comparison with the two other mammalian Id genes, Id1 and Id2, reveals a highly conserved protein coding gene organisation consistent with evolution from a common, ancestral Id-like gene. In addition, by using a yeast artificial chromosome (YAC) clone of Id3, we have fine-scale mapped the gene to chromosome band 1p36.1 by fluorescence in situ hybridisation (FISH) and, using the same FISH technique, we have detected heterogeneity in tumour-associated 1p36 chromosome translocations.

引用

页码：309 / 314

页数：6

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