ISOLATION AND CHARACTERIZATION OF RESPIRATION-DEFICIENT MUTANTS FROM THE PATHOGENIC YEAST CANDIDA-ALBICANS

被引：7

作者：

ABUHATAB, M ^{[1
]}

WHITTAKER, PA ^{[1
]}

机构：

[1] MAYNOOTH COLL,DEPT BIOL,MAYNOOTH,KILDARE,IRELAND

来源：

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY | 1992年 / 61卷 / 03期

关键词：

CANDIDA; MITOCHONDRIA; MUTANTS;

D O I：

10.1007/BF00584227

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The isolation of several respiration deficient mutants of the pathogenic yeast Candida albicans is described. These show greatly reduced respiration rates, loss of cytochromes aa3 and b, and reduced growth rates. All of the mutants had lost the ability to assimilate a wide range of carbon sources. Ultrastructural studies showed reduced development of mitochondrial cristae in the mutants. The mutants can be divided into three classes depending on their respiration responses to the addition of cyanide.

引用

页码：207 / 219

页数：13

共 29 条

[11] UNCOUPLING ACTIVITY OF A NEWLY DEVELOPED FUNGICIDE, FLUAZINAM [3-CHLORO-N-(3-CHLORO-2,6-DINITRO-4-TRIFLUOROMETHYLPHENYL)-5-TRIFLUOROMETHYL-2-PYRIDINAMINE] [J].