CRF PROVOKES THE RELEASE OF NOREPINEPHRINE BY HEMOCYTES OF VIVIPARUS-ATER (GASTROPODA, PROSOBRANCHIA) - FURTHER EVIDENCE IN FAVOR OF THE EVOLUTIONARY HYPOTHESIS OF THE MOBILE IMMUNE-BRAIN

被引:54
作者
OTTAVIANI, E
CASELGRANDI, E
FRANCHINI, A
FRANCESCHI, C
机构
[1] UNIV MODENA, INST HYG, I-41100 MODENA, ITALY
[2] UNIV MODENA, INST GEN PATHOL, I-41100 MODENA, ITALY
关键词
D O I
10.1006/bbrc.1993.1644
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The concentration of biogenic amines (norepinephrine, epinephrine and dopamine) was determined by HPLC in serum and hemocytes of the mollusc Viviparus ater following in vitro incubation of the hemolymph with corticotropin-releasing factor (CRF) for different periods of time. CRF provoked the release of norepinephrine from hemocytes into the serum, the maximum level being observed after 15 min. incubation. Moreover, immunoreactive tyrosine hydroxylase and dopamine β-hydroxylase, i.e., the enzymes involved in biogenic amine biosynthesis, have been demonstrated in hemocytes. These findings show that in invertebrates an ancestral type of stress response, similar to that performed by mammalian hypothalamic-pituitary-adrenal axis, occurs in phagocytic hemocytes, a cell type capable of both fundamental immune and neuroendocrine responses. © 1993 Academic Press.
引用
收藏
页码:446 / 452
页数:7
相关论文
共 19 条
[1]   STRESS HORMONES - THEIR INTERACTION AND REGULATION [J].
AXELROD, J ;
REISINE, TD .
SCIENCE, 1984, 224 (4648) :452-459
[3]   EFFECTS OF STRESS ON THE IMMUNE-SYSTEM [J].
KHANSARI, DN ;
MURGO, AJ ;
FAITH, RE .
IMMUNOLOGY TODAY, 1990, 11 (05) :170-175
[5]   ACTH-LIKE MOLECULES IN LYMPHOCYTES - A STUDY IN DIFFERENT VERTEBRATE CLASSES [J].
OTTAVIANI, E ;
FRANCHINI, A ;
COSSARIZZA, A ;
FRENCESCHI, C .
NEUROPEPTIDES, 1992, 23 (04) :215-219
[6]   ACTH-LIKE MOLECULES IN GASTROPOD MOLLUSKS - A POSSIBLE ROLE IN ANCESTRAL IMMUNE-RESPONSE AND STRESS [J].
OTTAVIANI, E ;
COSSARIZZA, A ;
ORTOLANI, C ;
MONTI, D ;
FRANCESCHI, C .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1991, 245 (1314) :215-218
[7]  
OTTAVIANI E, 1990, ANN NY ACAD SCI, V594, P454
[8]   THE PRESENCE OF IMMUNOREACTIVE VERTEBRATE BIOACTIVE PEPTIDE SUBSTANCES IN HEMOCYTES OF THE FRESH-WATER SNAIL VIVIPARUS-ATER (GASTROPODA, PROSOBRANCHIA) [J].
OTTAVIANI, E ;
FRANCHINI, A ;
FONTANILI, P .
CELLULAR AND MOLECULAR NEUROBIOLOGY, 1992, 12 (05) :455-462
[9]   EPINEPHRINE INVESTIGATION IN THE SNAIL BRAIN OF HELICELLA-VIRGATA (GASTROPODA, PULMONATA) [J].
OTTAVIANI, E ;
CASELGRANDI, E ;
FRANCHINI, A .
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 1988, 89 (02) :267-269
[10]   IMMUNOCYTOCHEMICAL EVIDENCE OF VERTEBRATE BIOACTIVE PEPTIDE-LIKE MOLECULES IN THE IMMUNE CELL-TYPES OF THE FRESH-WATER SNAIL PLANORBARIUS-CORNEUS (L) (GASTROPODA, PULMONATA) [J].
OTTAVIANI, E ;
COSSARIZZA, A .
FEBS LETTERS, 1990, 267 (02) :250-252