STRESS-INDUCED CHANGES IN MUSCARINIC AND BETA-ADRENERGIC BINDING-SITES ON RAT THYMOCYTES AND LYMPHOCYTES

被引：17

作者：

KUBERA, M ^{[1
]}

SKOWRONCENDRZAK, A ^{[1
]}

MAZURKOLECKA, B ^{[1
]}

BUBAKSATORA, M ^{[1
]}

BASTAKAIM, A ^{[1
]}

LASKOWSKABOZEK, H ^{[1
]}

RYZEWSKI, J ^{[1
]}

机构：

[1] RHEUMATOL INST,DEPT PATHOPHYSIOL,WARSAW,POLAND

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1992年 / 37卷 / 03期

关键词：

IMMOBILIZATION STRESS; LYMPHOCYTE; THYMOCYTE; MUSCARINIC RECEPTOR; BETA-ADRENERGIC RECEPTOR; NEURO-IMMUNOINTERACTION;

D O I：

10.1016/0165-5728(92)90007-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study examined the effect of immobilization stress on the expression of muscarinic and beta-adrenergic receptors on thymocytes and lymphocytes obtained from 5-month-old L-E male rats. After 2 h immobilization (acute stress) there was a significant increase in specific binding of [H-3]-DHA to beta-adrenergic receptors on thymocytes and on lymphocytes from the blood but not from the spleen, whereas [H-3]-QNB binding to muscarinic receptors in those cells was not altered in comparison with the undisturbed control. Chronic immobilization stress (5 days, for 2 h) decreased the [H-3]-QNB binding to lymphocytes collected from the spleen and blood but not from thymus; it caused neither a significant change in the H-3-DHA binding to thymocytes nor lymphocytes obtained from the blood and spleen.

引用

页码：229 / 235

页数：7