ASSOCIATION BETWEEN SCHIZOPHRENIA AND HOMOZYGOSITY AT THE DOPAMINE-D3 RECEPTOR GENE

被引：246

作者：

CROCQ, MA

MANT, R

ASHERSON, P

WILLIAMS, J

HODE, Y

MAYEROVA, A

COLLIER, D

LANNFELT, L

SOKOLOFF, P

SCHWARTZ, JC

GILL, M

MACHER, JP

MCGUFFIN, P

OWEN, MJ ^{[1
]}

机构：

[1] UNIV WALES COLL MED,DEPT PSYCHOL MED,HEATH PK,CARDIFF CF4 4XN,S GLAM,WALES

[2] UNIV WALES COLL MED,DEPT MED GENET,CARDIFF CF4 4XN,S GLAM,WALES

[3] CTR HOSP ROUFFACH,FORENAP,F-68250 ROUFFACH,FRANCE

[4] UNIV FREIBURG,INST HUMAN GENET,W-7800 FREIBURG,GERMANY

[5] INST PSYCHIAT,GENET SECT,LONDON SE5 8AF,ENGLAND

[6] INSERM,UNITE NEUROBIOL & PHARMACOL 109,F-75005 PARIS,FRANCE

来源：

JOURNAL OF MEDICAL GENETICS | 1992年 / 29卷 / 12期

关键词：

D O I：

10.1136/jmg.29.12.858

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).

引用

页码：858 / 860

页数：3