INVIVO AND INVITRO STUDIES ON THE EFFECT OF THE SEROTONINERGIC SYSTEM ON LUTEINIZING-HORMONE AND LUTEINIZING-HORMONE-RELEASING HORMONE-SECRETION IN PREPUBERTAL AND PERIPUBERTAL FEMALE RATS

被引：44

作者：

ARIAS, P ^{[1
]}

SZWARCFARB, B ^{[1
]}

DERONDINA, DC ^{[1
]}

CARBONE, S ^{[1
]}

SVERDLIK, R ^{[1
]}

MOGUILEVSKY, JA ^{[1
]}

机构：

[1] UNIV BUENOS AIRES,FAC MED,DEPT FIS,PARAGUAY 2155,RA-1121 BUENOS AIRES,ARGENTINA

来源：

BRAIN RESEARCH | 1990年 / 523卷 / 01期

关键词：

5-Hydroxytryptophan; Hypothalamic fragment; Incubation; Luteinizing hormone; Luteinizing hormone-releasing hormone; Puberty; Serotonin; Superfusion;

D O I：

10.1016/0006-8993(90)91634-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present investigations were designed to assess the effect of the serotoninergic system on luteinizing hormone (LH) and LH-releasing hormone (LH-RH) secretion in female rats aged 14 and 30 days. The administration of 5-hydroxytryptophan (5-HTP; 75 mg/kg i.p.) increased hypothalamic serotonin (5-HT) concentrations in both age groups, and did not affect hypothalamic norepinephrine (NE) concentration or release. Serum LH levels were raised by 5-HTP in 14-day-old, but not in 30-day-old rats. Basal and KC1- (28 mM) stimulated LH-RH release by incubated hypothalamic fragments was significantly enhanced when 5-HTP was injected previously to 14-day-old animals. In 30-day-old rats, 5-HTP treatment did not modify basal LH-RH release, and decreased the KC1-stimulated LH-RH output. Similarly, the addition of 5-HT (10-7M) to superfused hypothalamic fragments enhanced basal LH-RH release in 14-day-old rats and blocked the increment in LH-RH release evoked by KC1 in 30-day-old rats. the present results show that in 14-day-old female rats, the serotoninergic system (activated in vivo by 5-HTP treatment, or in vitro by 5-HT addition) exerts a stimulatory effect on LH-RH, and thus, on LH release. On the contrary, in 30-day-old animals, stimulated LH-RH secretion was inhibited by 5-HT. Apparently, the hypothalamic NE system is not implicated in this response. The participation of this changing effect of 5-HT on LH-RH/LH release at the onset of puberty is postulated. © 1990.

引用

页码：57 / 61

页数：5

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