ENANTIOMER SEPARATIONS BY NORMAL HPLC SYSTEMS WITH PERMETHYLATED BETA-CYCLODEXTRIN DYNAMICALLY COATED ON SILICA SOLID SUPPORTS

被引:12
作者
PAWLOWSKA, M
机构
[1] Institute of Physical Chemistry, 01-224, Warsaw
来源
JOURNAL OF LIQUID CHROMATOGRAPHY | 1991年 / 14卷 / 12期
关键词
D O I
10.1080/01483919108049690
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The paper describes the technique of solvent-generated liquid-solid chromatography with a chiral stationary phase consisting of permethylated beta-cyclodextrin coated on a bare silica surface. The chiral adsorption layer was generated dynamically by pumping diluted solutions of permethylated beta-cyclodextrin in binary (hexane/different alcohols) eluents through a column packed with microparticulate silica. This technique leads to column with excellent time stability and good reproducibility of the enantioselectivity. It was found that retention characteristics e.g. enantioselectivity and capacity depend very strongly on the type and concentration of the alcohol used as mobile phase component.
引用
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页码:2273 / 2286
页数:14
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