N-3 VERSUS N-6 FATTY-ACID INCORPORATION INTO THE PHOSPHOLIPIDS OF RAT-HEART SARCOLEMMA - A COMPARATIVE-STUDY OF 4 DIFFERENT OIL DIETS

被引:16
作者
ALMAKDESSI, S
SWEIDAN, H
JACOB, R
机构
[1] Institute of Physiology II, University of Tübingen, Tubingen
关键词
SARCOLEMMA; N-3 FATTY ACIDS; N-6 FATTY ACIDS; FISH OIL; LINSEED OIL; CORN OIL; COCONUT OIL; N-3/N-6; RATIO; DOUBLE BOND INDEX;
D O I
10.1006/jmcc.1994.1004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The fatty acid (FA) composition of the phospholipids of rat heart sarcolemma was studied after a 10-week feeding period of diets containing 10% of each of coconut oil, corn oil, linseed oil, and fish oil in comparison to a low fat diet. The major modifications observed were the following: (1) a general increase of the n-6 FA family upon corn oil administration; (2) a dual effect of linseed oil in increasing 18:2 n-6 (more than did corn oil) and decreasing 20:4 n-6 and 22:4 n-6. At the same time n-3 FA increased significantly; and (3) a significant fall in the n-6 FA following fish oil, and a marked rise in the n-3 FA. The 10-fold increase in 22:6 n-3 supports the hypothesis of an inhibition of arachidonate synthesis, as well as that of the competition for the incorporation sites of phospholipids. In general, the n-3 FA diets produced the replacement of the n-6 FA by the n-3 FA in membrane phospholipids, and led to a significant increase of the double bond index (DBI). © 1993 Academic Press Limited.
引用
收藏
页码:23 / 29
页数:7
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