SILENCING IS GOLDEN - NEGATIVE REGULATION IN THE CONTROL OF NEURONAL GENE-TRANSCRIPTION

被引：141

作者：

SCHOENHERR, CJ

ANDERSON, DJ

机构：

[1] Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91106

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1995年 / 5卷 / 05期

关键词：

D O I：

10.1016/0959-4388(95)80060-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent work has identified negative-acting DNA regulatory elements that function to prevent the expression of neuronal genes in non-neuronal cell types or in inappropriate neuronal subtypes. In some cases. the protein factors that interact with these silencer elements have been isolated and characterized. For example, the recently cloned silencer-binding factor NRSF/REST is a novel zinc-finger protein that interacts with silencer elements in a number of neuron-specific genes. These data suggest that negative regulation plays a major role in determining the diverse patterns oi gene expression within the nervous system.

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收藏

页码：566 / 571

页数：6

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