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GENETIC-MAPPING OF THE ECOTROPIC MURINE LEUKEMIA VIRUS-INDUCING LOCUS OF BALB-C MOUSE TO CHROMOSOME-5

被引：107
作者：
KOZAK, CA
ROWE, WP
机构：
[1] Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda
来源：
SCIENCE | 1979年 / 204卷 / 4388期
关键词：
D O I：
10.1126/science.219475
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
By means of an approach that combined the techniques of somatic cell genetics and Mendelian breeding studies, the inducibility locus, designated Cv, for ecotropic marine leukemia virus in BALBIc mice, was mapped to chromosome 5, 23 units from the locus for phosphoglucomutase-1, with gene order Cv-Pgm-1-Gus. This low-efficiency inducibility locus is therefore not allelic with the chromosome 7 loci previously described for two other mouse strains with high virus inducibility. These studies provide further evidence that endogenous ecotropic viruses represent viral genomes inserted at different chromosomal sites in the various mouse strains. Copyright © 1979 AAAS.
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页码：69 / 71
页数：3
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