A SUBSET OF P53-DEFICIENT EMBRYOS EXHIBIT EXENCEPHALY

被引：492

作者：

SAH, VP

ATTARDI, LD

MULLIGAN, GJ

WILLIAMS, BO

BRONSON, RT

JACKS, T

机构：

[1] MIT,CTR CANC RES,DEPT BIOL,CAMBRIDGE,MA 02139

[2] TUFTS UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02111

[3] TUFTS UNIV,SCH VET MED,DEPT PATHOL,BOSTON,MA 02111

来源：

NATURE GENETICS | 1995年 / 10卷 / 02期

关键词：

D O I：

10.1038/ng0695-175

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Defects in neural tube formation are among the most common malformations leading to infant mortality. Although numerous genetic loci appear to contribute to the defects observed in humans and in animal model systems, few of the genes involved have been characterized at the molecular level, Mice lacking the p53 tumour suppressor gene are predisposed to tumours, but the viability of these animals indicates that p53 function is not essential for embryonic development. Here, we demonstrate that a fraction of p53-deficient embryos in fact do not develop normally. These animals display defects in neural tube closure resulting in an overgrowth of neural tissue in the region of the midbrain, a condition known as exencephaly.

引用

页码：175 / 180

页数：6

共 38 条

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