Migraine occurring at menstruation is frequently difficult to treat. A 38-year-old woman with exceptionally severe menstrual migraine was treated by temporary ovarian suppression using Zoladex, a long acting luteinizing hormone-releasing hormone agonist. There was prompt relief of headache, and after several months of treatment the patient elected to undergo surgical oophorectomy with subsequent resolution of her migraine. A trial of reversible hypogonadism using an LHRH agonist may thus be helpful in predicting the result of surgical castration in this situation.
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页码:164 / 165
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McLachlan RI, Healy DL, Burger HG, Clinical aspects of LHRH analogues in gynaecology: a review, Br J Obstet Gynaecol, 93, pp. 431-454, (1986)