ACTIVATION OF PRODRUGS BY TARGETED ENZYMES

被引：12

作者：

HELLSTROM, KE

SENTER, PD

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Seattle, WA 98121

来源：

EUROPEAN JOURNAL OF CANCER | 1991年 / 27卷 / 11期

关键词：

D O I：

10.1016/0277-5379(91)90003-V

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页码：1342 / 1343

页数：2

共 12 条

[1]

ALEXANDER RP, 1991, TETRAHEDRON LETT, V27, P3269

[2] DISPOSITION OF THE PRODRUG 4-(BIS (2-CHLOROETHYL) AMINO) BENZOYL-L-GLUTAMIC ACID AND ITS ACTIVE PARENT DRUG IN MICE [J].

ANTONIW, P ;

SPRINGER, CJ ;

BAGSHAWE, KD ;

SEARLE, F ;

MELTON, RG ;

ROGERS, GT ;

BURKE, PJ ;

SHERWOOD, RF .

BRITISH JOURNAL OF CANCER, 1990, 62 (06) :909-914

[3] A CYTO-TOXIC AGENT CAN BE GENERATED SELECTIVELY AT CANCER SITES [J].

BAGSHAWE, KD ;

SPRINGER, CJ ;

SEARLE, F ;

ANTONIW, P ;

SHARMA, SK ;

MELTON, RG ;

SHERWOOD, RF .

BRITISH JOURNAL OF CANCER, 1988, 58 (06) :700-703

[4] THE 1ST BAGSHAWE LECTURE - TOWARDS GENERATING CYTO-TOXIC AGENTS AT CANCER SITES [J].

BAGSHAWE, KD .

BRITISH JOURNAL OF CANCER, 1989, 60 (03) :275-281

[5]

BAGSHAWE KD, 1991, ANTIBODY IMMUNOCONJU, V4, P204

[6] ANTIBODY-PENICILLIN-V-AMIDASE CONJUGATES KILL ANTIGEN-POSITIVE TUMOR-CELLS WHEN COMBINED WITH DOXORUBICIN PHENOXYACETAMIDE [J].

KERR, DE ;

SENTER, PD ;

BURNETT, WV ;

HIRSCHBERG, DL ;

HELLSTROM, I ;

HELLSTROM, KE .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 1990, 31 (04) :202-206

[7] ACTIVATION OF PRODRUGS BY ANTIBODY-ENZYME CONJUGATES - A NEW APPROACH TO CANCER-THERAPY [J].

SENTER, PD .

FASEB JOURNAL, 1990, 4 (02) :188-193

[8] ANTI-TUMOR EFFECTS OF ANTIBODY ALKALINE-PHOSPHATASE CONJUGATES IN COMBINATION WITH ETOPOSIDE PHOSPHATE [J].

SENTER, PD ;

SAULNIER, MG ;

SCHREIBER, GJ ;

HIRSCHBERG, DL ;

BROWN, JP ;

HELLSTROM, I ;

HELLSTROM, KE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (13) :4842-4846

[9]

SENTER PD, 1989, CANCER RES, V49, P5789

[10] A NOVEL TARGETED DELIVERY SYSTEM UTILIZING A CEPHALOSPORIN-ONCOLYTIC PRODRUG ACTIVATED BY AN ANTIBODY BETA-LACTAMASE CONJUGATE FOR THE TREATMENT OF CANCER [J].

SHEPHERD, TA ;

JUNGHEIM, LN ;

MEYER, DL ;

STARLING, JJ .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1991, 1 (01) :21-26

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