THE STABILITY OF DUPLEX DNA CONTAINING 3,N-4-ETHENO-2'-DEOXYCYTIDINE (EPSILON-DC) - A UV MELTING AND HIGH-RESOLUTION H-1-NMR STUDY

被引：8

作者：

GIBSON, NJ

PARKINSON, JA

BARLOW, T

WATSON, WP

BROWN, T

机构：

[1] UNIV EDINBURGH,DEPT CHEM,EDINBURGH EH9 3JJ,MIDLOTHIAN,SCOTLAND

[2] SHELL RES LTD,SITTINGBOURNE RES CTR,SITTINGBOURNE ME9 8AG,KENT,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 19期

关键词：

D O I：

10.1039/c39940002241

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The mutagenic lesion 3,N-4-etheno-2'-deoxycytidine (epsilon dC) greatly destabilises DNA when paired with each of the natural bases although the solution structure of a duplex containing a epsilon C : A pair shows that the lesion does not greatly disrupt base pairing in the duplex.

引用

页码：2241 / 2242

页数：2

共 12 条

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[12] 1,N-6-ETHENO DEOXY AND RIBO ADENOSINE AND 3,N-4-ETHENO DEOXY AND RIBO CYTIDINE PHOSPHORAMIDITES - STRONGLY FLUORESCENT STRUCTURES FOR SELECTIVE INTRODUCTION IN DEFINED SEQUENCE DNA AND RNA MOLECULES [J].

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NUCLEIC ACIDS RESEARCH, 1994, 22 (07) :1296-1304

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