POCKETING THE DIFFERENCE - STRUCTURES OF URACIL EXCISION-REPAIR PROTEINS

被引：8

作者：

ELLENBERGER, T

机构：

来源：

CHEMISTRY & BIOLOGY | 1995年 / 2卷 / 06期

关键词：

D O I：

10.1016/1074-5521(95)90213-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The recognition of abnormal DNA structure by proteins is fundamentally different from sequence-specific DNA binding, Recent crystal structures of uracil-DNA glycosylases show a novel uracil-binding pocket that explains the enzyme's selectivity for uracil-containing DNA and provide a structural basis for exploring the catalytic mechanism of amino-glycosylic bond cleavage.

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页码：351 / 354

页数：4

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