ASYMMETRIC CONJUGATE ADDITIONS TO CHIRAL BICYCLIC LACTAMS - A STEREOSELECTIVE GENERAL-SYNTHESIS OF CHIRAL 3-AMINOPYRROLIDINES

被引：35

作者：

ANDRES, CJ ^{[1
]}

LEE, PH ^{[1
]}

NGUYEN, TH ^{[1
]}

MEYERS, AI ^{[1
]}

机构：

[1] COLORADO STATE UNIV,DEPT CHEM,FT COLLINS,CO 80523

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 10期

关键词：

D O I：

10.1021/jo00115a040

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereoselective, conjugate additions of primary amines to chiral bicyclic lactams are described. Typical yields ranged from 80% to 90% with facial diastereoselectivities ranging from 95:5 to >98:2. Several optically pure amino bicyclic lactams were transformed by reductive cleavage, in two steps, to chiral 3-aminopyrrolidines.

引用

页码：3189 / 3193

页数：5

共 24 条

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