P-32 POSTLABELING ANALYSIS OF DNA-ADDUCTS IN DIFFERENT POPULATIONS

被引：14

作者：

SCHELL, C

POPP, W

KRAUS, R

VAHRENHOLZ, C

NORPOTH, K

机构：

[1] Institute of Hygiene and Occupational Medicine, University Medical Center, 45147 Essen

来源：

TOXICOLOGY LETTERS | 1995年 / 77卷 / 1-3期

关键词：

P-32; POSTLABELING; DNA ADDUCTS; PAH; LYMPHOCYTES;

D O I：

10.1016/0378-4274(95)03310-6

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Blood samples were obtained from different populations exposed occupationally or by lifestyle habits to polycyclic aromatic hydrocarbons (PAH). DNA adducts were determined by P-32-postlabeling assay either in white blood cells (WBC) or lymphocytes. The level of DNA adducts ranged from 1.5 per 10(9) nucleotides in one of the control groups up to 7.1 per 10(9) nucleotides in one group of PAH-exposed workers. Comparison of the adduct thin layer chromatography (TLC) profiles revealed individual variation in both pattern and level of DNA adducts. Significant differences of adduct levels were detected between one group of PAH-exposed coke-oven workers and the corresponding Control group. Only a weak influence of the smoking habits on the amount of adducts was detectable in occupationally exposed or unexposed individuals.

引用

页码：299 / 307

页数：9

共 31 条

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