SUPERCRITICAL FLUID EXTRACTION - SUPERCRITICAL FLUID CHROMATOGRAPHY FOR ANALYSIS OF A PROSTAGLANDIN - HPMC DISPERSION

被引：6

作者：

ROSTON, DA

机构：

[1] Searle Research and Development, Skokie, IL, 6077

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1992年 / 18卷 / 02期

关键词：

D O I：

10.3109/03639049209043697

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An on-line SFE-SFC system was used to extract and chromatograph a synthetic prostaglandin from hydroxypropyl methylcellulose (HPMC), which is a widely used material in controlled-release drug formulations. The only sample preparation for the on-line SFE-SFC analysis of the dispersion was weighing the sample into the extraction vessel insert. The extraction efficiency for a four-minute extraction was approximately 65%.

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页码：245 / 255

页数：11

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