PLASMA-CLEARANCE AND PLASMA HALF-DISAPPEARANCE TIME OF EXOGENOUS THYROTROPIN-RELEASING-HORMONE AND PYROGLUTAMYL-N3IM-METHYL-HISTIDYL PROLINEAMIDE

被引：32

作者：

MORLEY, JE

GARVIN, TJ

PEKARY, AE

UTIGER, RD

NAIR, MG

BAUGH, CM

HERSHMAN, JM

机构：

[1] UNIV CALIF LOS ANGELES, LOS ANGELES, CA 90024 USA

[2] UNIV PENN, SCH MED, ENDOCRINE SECT, PHILADELPHIA, PA 19174 USA

[3] UNIV S ALABAMA, DEPT BIOCHEM, MOBILE, AL 36688 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1979年 / 48卷 / 03期

关键词：

D O I：

10.1210/jcem-48-3-377

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The plasma clearance rate (PCR) and plasma half-disappearance time (t1/2) of TRH was compared to the PCR and t1/2 of pyroglutamyl-N3im-methyl-histidyl prolineamide (methyl-TRH), a more potent analog of TRH in normal subjects. The PCR for TRH was 1500 ± 329 (SD) ml/min, which was significantly greater than the PCR of methyl-TRH (783 ± 96 ml/min). The t1/2 of TRH was 6.2 min compared to a t1/2 of 11.5 min for methyl-TRH. The slower clearance of methyl-TRH is probably due to the increased resistance to degradation by serum enzymes of methyl-TRH compared to TRH. © 1979 by The Endocrine Society.

引用

页码：377 / 380

页数：4