LEWIS ACID-PROMOTED REACTION OF BETA,BETA-DIFLUORINATED N,O-ACETAL WITH SILYLATED NUCLEOPHILES

被引：14

作者：

TSUKAMOTO, T ^{[1
]}

KITAZUME, T ^{[1
]}

机构：

[1] TOKYO INST TECHNOL, DEPT BIOENGN, NAGATSUTA, MIDORI KU, YOKOHAMA, KANAGAWA 227, JAPAN

来源：

CHEMISTRY LETTERS | 1992年 / 07期

关键词：

D O I：

10.1246/cl.1992.1377

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lewis acid-promoted reaction of ethyl 3-ethoxy-2,2-difluoro-3-(dimethylamino)-propionate (1) with some silylated nucleophiles afforded beta,beta-difluoroamines in good yields. The formation of iminium ion intermediate from 1 and BF3.OEt2 was confirmed by F-19 and C-13 NMR spectroscopy.

引用

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页码：1377 / 1380

页数：4

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