INTERACTION BETWEEN TRANSCRIPTION FACTORS SP1 AND YY1

被引：263

作者：

SETO, E ^{[1
]}

LEWIS, B ^{[1
]}

SHENK, T ^{[1
]}

机构：

[1] PRINCETON UNIV,HOWARD HUGHES MED INST,DEPT MOLEC BIOL,PRINCETON,NJ 08544

来源：

NATURE | 1993年 / 365卷 / 6445期

关键词：

D O I：

10.1038/365462a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A BASAL level of transcription is usually observed when all but a small region of DNA has been deleted from a eukaryotic gene promoter. These promoter elements, which are necessary and sufficient for specific transcription initiation, are referred to as minimal or core promoter elements. One element that is commonly present in a core promoter is the initiator. It has been demonstrated that the presence of Sp1 binding sites can greatly enhance the level of transcription initiation at initiator elements1-4. A binding site for the YY1 transcription factor, located at the initiation site of the adeno-associated virus P5 promoter, functions as an initiator element; a synergistic enhancement of its activity is observed in vitro when upstream Sp1 binding sites are present3. Here we report that this synergistic activation probably occurs through protein-protein interactions.

引用

页码：462 / 464

页数：3

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